منابع مشابه
Hypertension: the missing WNKs.
The With no Lysine [K] (WNK) family of enzymes are central in the regulation of blood pressure. WNKs have been implicated in hereditary hypertension disorders, mainly through control of the activity and levels of ion cotransporters and channels. Actions of WNKs in the kidney have been heavily investigated, and recent studies have provided insight into not only the regulation of these enzymes bu...
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In a lifetime of observing and participating in politics, the world wide campaign by the international green movement (aided by the power-seeking UN bureaucracy) to monitor, control and tax every food, energy and transport business in the world is the most dangerous development I have ever seen. It has the potential to blight the lives and investments of the majority of Australians who are unab...
متن کاملCotransporters, WNKs and hypertension: important leads from the study of monogenetic disorders of blood pressure regulation.
Major advances are being made in identifying the structure and behaviour of regulatory cascades that control the activity of cation-Cl(-) cotransporters and certain Na(+), K(+) and Cl(-) channels. These transporters play key roles in regulating arterial blood pressure as they are not only responsible for NaCl reabsorption in the thick ascending limb and distal tubule of the kidney, but are also...
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Synchrony between local field potential (LFP) rhythms is thought to boost the signal of attended sensory inputs. Other cognitive functions could benefit from such gain control. One is categorization where decisions can be difficult if categories differ in subtle ways. Monkeys were trained to flexibly categorize smoothly varying morphed stimuli, using orthogonal boundaries to carve up the same s...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2001
ISSN: 1471-0056,1471-0064
DOI: 10.1038/35093520